This classic horror shoot 'em up from Rebellion works very well in Wine
The mouse virtualisation bug (6971) is still outstanding, but only affects the game in windowed mode.
A workaround has been added in wine-1.1.3, enabling very near perfect gameplay [see the version 1.0 HOWTO] in wine-1.1.4 (where a regression bug was fixed). Only relatively minor sound glitches remain.
The open source implementation of the game, which used to be a viable alternative to wine, is no longer maintained, and relies on some rather old tools and libraries.