You can run TomTom Home :
wine .wine/drive_c/Program\ Files/TomTom\ HOME\ 2/TomTomHOME.exe
The following comments are owned by whoever posted them. WineHQ is not responsible for what they say.
TomTom Home not detecting device
by Michael on Friday February 4th 2011, 19:26
With my 910 connected via the USB port and with the Drives tab of Wine configuration running, if I choose E:/media/TomTom Disk and play around with the Type and then select Apply (if it dark not greyed out), a red cross appears on my 910. Wine config is at least communicating partially with my 910.
I don't understand why my Type selections always default back to Autodetect. This might be significant. I have had some success with Garmin software running under Wine, it is able to communicate with my usb connected Edge 705 GPS if I select Floppy in the Type box.
RE: Hints for device detection failure
by Wolf Butler on Friday March 28th 2008, 13:48
TomTom seems to be pretty non-responsive if you query them about anything involving Linux. I sent them two requests for information about possible Linux ports and also volunteered to be a beta tester for them for a Linux version of TomTomHome (when they were soliciting such volunteers late last year). I've never received anything back from them.
Also- for the record- the latest TomTom's (Like TomTomOne v3) don't work with Macs either. The Mac version of the Home software doesn't recognize them at all. TomTom's "solution" when I contacted them through technical suppor: Run Windows. :(
I really do hope a solution is found soon. There were only two things I use that don't work in Linux- iTunes and TomTomHome. iTunes works now.