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starting the game, playing a bit on low res./ details, changing resolution and details works fine. Some options will produce artifacts, see below.
What does not
Adding much details does not work, as soon as you do, application starts to get slower and slower... (render errors too, see bug section below)
Also, the game does not reset the resolution after it's shutdown... (though it seems to be a clean one: http://pastebin.com/f7e8d7803). I start R6V in a virtual desktop (see winecfg-graphics) to keep correct resolution.
The mouse bug can also be found here, see below... (6971)