The test results you have selected are very old and may not represent the current state of Wine.
Selected Test Results (selected in 'Test Results' table below)
Installing the game and DirectX
Validating/entering license key
What does not
Game will not start.
What was not tested
Playing the game, for obvious reasons.
You will need to download microsoft.vc80.crt.zip and move the files in the folder into the DefenseGrid folder. However, the game will not start and there are no error messages. This may be due to my 64-bit operating system.