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Everything seems to work so far
What does not
What was not tested
I've only played 10 seconds into the game, but graphics seem fine, sound works, characters move when you click on a spot on the screen, etc.
Another reviewer mentioned that you need to set the windows version to Vista to make this work; that's what I'm doing.
An up to date version of wine is necessary to make this work. With the default Ubuntu download I got an error (I think related to Compiz which was running at the same time.) See: http://www.winehq.org/download/deb for their repository
When exiting the game, compiz was really slow, but I switched to metacity (metacity --replace &) and back to compiz (compiz --replace &) and things seem fine now. I have a T61 btw. I did not need to install any Securom patch