Nexus doesn't work in Wine, and loading the dlls for it sometimes causes problems. If you want to use the Nanoboards with AD2009, you are going to have to run Windows instead.
There are several bugs, as can be seen above, but AD2009 is functional enough to design a PCB. Get used to working around the bugs before you dive in.
What Works?
As of Wine-1.2rc4
Almost everything. There are no noticeable bugs in the schematic editor. Online supplier links work if you install IE6 and msxml4 with winetricks. Licensing and logging into Altium.com works. PCB editor works well, 3D PCB view works, but will generate an error when you close it. See buglist above for details. Autorouting and DRC work. Scripting works. Spice simulation works. Printing has issues, see the buglist.
What does NOT work?
Nexus and FPGA tools. If you need these features, I'd recommend just using Windows. I don't know if Wine will ever support Windows device drivers. Theoretically, someone could write a replacement dll for the parallel port and USB drivers to connect to the hardware using user space libraries in Linux. Don't hold your breath for that.
Camtastic also does not work properly. The display is corrupted. Good news is that gerbv is an acceptable alternative. It's what I use to view the CAM files.
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Altium installer need mdac25 component (+)
by George Gaal on Sunday April 4th 2010, 8:19