The test results you have selected are very old and may not represent the current state of Wine.
Selected Test Results (selected in 'Test Results' table below)
What does not
Nothing works, when Steam tries to install the game, it throws the following error:
Incomplete Installation of Serious Sam HD (53)"
This seems to be caused by the Steam update which affects Modern Warfare 2 on Steam too (bug #20736).
What was not tested
The game wasn't tested with a no-steam crack, this could maybe solve the problem (will test it out ASAP).