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What works
The game runs extremely well with its dependencies installed (listed under extra comments). It's playable for economics and trade but not the best for combat.
Alternatively run winetricks and use the interface to manually select what you want - take note that everything above is recommended for FOM; d3dx9, dinput8, vcrun2008 and wininet are requirements.
Now run the FOM installer like you would any other Wine application.
When FOM has installed run it and perform a complete check. You can now either click Start to patch through the launcher or you can quit the launcher and extract the any patches from your Windows installation to ~/.wine/drive_c/"Program Files/Face of Mankind/PatchTmp/Download". If you go with the latter run the launcher again and the patches will be installed without downloading.
Mouse Cursor Issue
Until bug 6971 is fixed you can improve the gameplay by setting mouse sensitivity and mouse smoothing to their maximum level (ingame). This stops the cursor leaving the window quickly. You can also re-centre the mouse by tapping LEFT-CTRL (which toggles the menu).
Another suggestion (not tried) is to turn on virtual desktop in winecfg.
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Launcher Error
by Gibbs on Sunday October 10th 2010, 17:12
You may need to install urlmon if you get an immediate error when loading the launcher. With winetricks: