What works

Installing.

Patching to v1.05.

Playing.

What does not
Nothing I tried.

What was not tested
Direct3D mode.

Extended play.

Multiplayer.

Additional Comments

For those interested this game can be setup to play without needing the cd in your computer or having to mount an image.
This is how to do it::

Step 1: Install the game from the cd.

Step 2: Patch to the latest version 1.05.

Step 3: Create a new folder on your computer, lets call it "CD", open up the "Drives" tab in "winecfg", and set this folder as a new drive. Click on "Advanced" and make sure "CD-ROM" is checked, not "Autodetect".

Step 4: Copy the files "Entities.dll" and "SeriousSam.exe" from the game cd into the "CD" folder. These files are located in the "Install/Bin" folder on the game cd. Make sure to keep the file structure intact. In other works the "CD" folder should contain a folder named "Install", which contains a folder
named "Bin", which contains the two files.

Step 5: In the root of the "CD" folder create the hidden files ".windows-label" and ".windows-serial". In the ".windows-label" file place the label of the cd, and in the ".windows-serial" place the serial. These can be found by placing the original cd into your computer, opening the "Drives" tab in "winecfg",
highlighting your cdrom drive and clicking on "Advanced". In my case it was:
Label:SamFE_Gold   Serial:5689CB0C

And that should be it. The game should now play without the cd.