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I've tried installing it and get always the message '[INTERNAL] Failed to register into GameExplorer!', after I accept the Setup.exe quits and removes the Might and Magic Heroes 6 folder, but not the Ubisoft Game Launcher folder.
If I kill Setup.exe when the message is displayed, I am able to start the game, but it doesn't leave the start-screen behind. I can't patch the game, because, as far as the registry is concerned, it is not installed. Nothing works at all so far.
But there is hope. This error is common by Vista-users, giving them a hard time to install the game as well. So maybe Ubisoft will fix this.