The test results you have selected are very old and may not represent the current state of Wine.
Selected Test Results (selected in 'Test Results' table below)
What does not
QuickTime installation, it displayed license agreement, when clicked "Agree", it immediately terminated (and game's installer warned about the failure too).
The game itself, it didn't detect CD and showed an error: "Please put the I Love Science! CD in a CD drive".
What was not tested
Playing the game.
The game itself seems to be a Win16 application (the main executable was 16-bit and it supports Windows 3.1)
It also depends on QuickTime 22.214.171.124 16-bit (bundled), which failed to install as mentioned.
Tested with WINE's Windows version 3.1/95/98/XP
Using ATI Radeon HD 4670 graphics (fglrx driver) and Intel HDA/Realtek ALC880 audio (ALSA) with WINE's winealsa.drv
WINE installed without GStreamer, OpenCL, XInput2 and OSS support.