What works
Downloading via Origin, Installing From Ashes & Resurgence DLC, Starting game through Origin, some singleplayer, gameplay in fullscreen mode.

What does not
Gameplay in virtual desktop.

What was not tested
Gameplay on Nvidia card, starting through Reloaded crack, entire campaign, Multiplayer.

Additional Comments

Origin may sometimes interfere with game startup. Use of Reloaded crack may change results here.

Virtual desktop creates very choppy audio/video, game only works in fullscreen mode.

Game may crash at the start of playing Bioware/EA logo. If so, the following patch might work (use it only with ME3 and at your own risk):

diff --git a/dlls/wined3d/query.c b/dlls/wined3d/query.c
index 8298058..ff55537 100644
---a/dlls/wined3d/query.c
+++b/dlls/wined3d/query.c
@@ -75,7 +75,7 @@ static enum wined3d_event_query_result wined3d_event_query_test(const struct win
                                 break;

                         case GL_TIMEOUT_EXPIRED:
-                               ret = WINED3D_EVENT_QUERY_WAITING;
+                               ret = WINED3D_EVENT_QUERY_OK;
                                 break;

                         case GL_WAIT_FAILED:
@@ -396,6 +396,7 @@ static HRESULT wined3d_event_query_ops_get_data(struct wined3d_query *query,
                         break;

                 case WINED3D_EVENT_QUERY_WAITING:
+                       FIXME("Event query is waiting.\n");
                         *data = FALSE;
                         break;

Thanks to cluthz and thanoulas from Portingteam.com for the patch.