Enhancement in two steps

Step 1:

If you have a good computer but still have lag (sound & game), you should set a real value using regedit.

REGEDIT4

[HKEY_CURRENT_USER\Software\Wine\Direct3D]
"VideoMemorySize"="256"

By default wine guess you have only 64.

Step 2:

Also you can use nice command to rise execution priority:

WINEDEBUG=-all env WINEPREFIX="/home/${USER}/.wine" nice -20 wine "C:\games\SimCity4\Apps\SimCity 4.exe" -intro:off

Registry tweaks:


[HKEY_CURRENT_USER\Software\Wine\Direct3D]
"DirectDrawRenderer"=""

gdi - Use GDI to draw on the screen (slow but reliable) (default) 
opengl - Use OpenGL (fast but not all programs work correctly)]

backbuffer: the rendering is done in the backbuffer (default)
pbuffer:    uses PixelBuffers
fbo:        uses Framebuffer object

auto:     same as readdraw at the moment, will do benchmarks and use best method later(default)
disabled: effectively disables render target locking
readdraw: uses glReadPixels for reading, glDrawPixels for drawing
readtex:  reading with glReadPixels, drawing by drawing a textured quad
texdraw:  readback using a texture, drawing with glDrawPixels
textex:   readback using a texture, drawing with a textured quad]

[When set to "enabled", this enables the use of GL Shading Language for vertex
and pixel shaders, as long as the hardware supports it.  This is experimental
at the moment, and not fully implemented.]

[Sets the amount of emulated video memory. Default is 64 (that results in 64MB),
in the future some automatic ways to obtain the real value should be added.]

By default, SimCity 4 only allows you to use resolutions up to 1280x1024, but it's very easy to use any resolution you want, just add this to your launcher/start script:

-CustomResolution:enabled -r1920x1080x32

Replace 1920x1080 with your desired resolution.