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Create, modify, and annotate pdf files using Adobe Acrobat Pro.
Acrobat Pro is one of the applications in Munich's wish list (see LiMuxWineKellerApplications), and is #92 in Amazon.com's sales rank, so what the heck, let's get it running on Wine.
See bugs.winehq.org's list of acrobat pro bugs
Automating Acrobat (might be useful for regression tests):
http://www.adobeforums.com/cgi-bin/webx?13@@.3bbedaa6 (forum for discussing automation)
http://www.evermap.com/autobatch.asp (a plugin to let you run acrobat pro batches from commandline)
http://www.autohotkey.com/forum/topic10739.html (one guy who used autohotkey to automate one thing