I'm a newbie to Wine but I was able to get 123D Design to work.
Download 123D Design (I installed the 64-bit version)
Install winetricks (search for installation instructions -- it's not difficult)
Use winetricks to Install Visual Studio Redistributables
Run the installation program
Follow the prompts as usual. If you get any errors about installing Visual Studio Redistributables, click "Ignore". At the end of the installation, you should get a 123D Design icon on your desktop. Double-click it run.
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