Neverwinter Nights II and Mask of the Betrayer install from DVD out of the box.
Autoupdate works out of the box after right-clicking and selecting "dedicated internet connection".
Game starts only after installing vcrun2005 and directx9 via winetricks (d3dx9 is not enough!).
Single player works great, as far as I can tell (tested character creation, tutorial, chapter 1 of the original campaign).
What does not
Everything seemed to work after installing vcrun2005 and directx9 via winetricks and changing some settings in winecfg (see additional comments below).
What was not tested
I had to enable "emulate a virtual desktop" in winecfg, otherwise the resolution was restricted to 1280x960; this seems to be an issue that only affects Nvidia cards, see bug 11558. Gentoo's PulseAudio driver for Wine does not work with the game (no sound), probably due to the directx9 winetrick. The standard Wine Alsa driver works perfectly. I experienced one crash, it occurred during the first battle of the single-player campaign. Don't know if it's a bug in the game or in Wine. Was unable to reproduce it.
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Linux Mint 18 "Sarah" x86_64||Jan 06 2017||1.8.6||Yes||Yes||Gold||Johan M. Cos|
|Show||openSUSE Leap 42.2 x86_64||Dec 09 2016||1.9.24||Yes||Yes||Gold||LokiDrow|
|Show||Ubuntu 15.10 "Wily" amd64 (+ variants like Kubuntu)||Dec 07 2015||1.6.2||Yes||Yes||Gold||an anonymous user|
|Show||Ubuntu 14.04 "Trusty" amd64 (+ variants like Kubuntu)||Mar 26 2014||1.6.2||Yes||Yes||Gold||an anonymous user|
|Show||Gentoo Linux x86_64||Jun 13 2013||1.6-rc1||Yes||Yes||Silver||RadosÅ‚aw SzkodziÅ„ski|
|Bug #||Description||Status||Resolution||Other apps affected|
|11558||Problem setting resolution in Neverwinter Nights 2||NEW||View|
|24602||NWN2 suffers from shadows flickering on ATI cards (fglrx driver)||RESOLVED||NOTOURBUG||View|
|32395||Neverwinter Nights 2 : Broken sky with anti-aliasing turned on||NEW||View|
OffscreenRenderingMode = fbo
UseGLSL = enabled
VideoMemorySize = 256
You may also put in whatever amount of memory your video card uses instead of 256.