What does not
You can't alt-tab out of the game, it will freeze (I'm not sure if this works on Windows). It will also freeze if something else (calendar) tries to steal focus, see HowTo for workaround.
What was not tested
If you can get Steam running, this should just work. I am running the nvidia proprietary driver on a 750 Ti, but have also run it using the Nouveau driver with no ill effects. Tested with this PPA - https://launchpad.net/~bryanquigley/+archive/ubuntu/wine
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||macOS Mojave 10.14||Jan 05 2020||4.0.3||Yes||Yes||Yes||Gold||Lukas Charvat|
|Show||Gentoo Linux x86_64||Apr 12 2018||3.5||Yes||No||No||Garbage||Michele|
|Show||Ubuntu 17.10 "Artful" amd64 (+variants like Kubuntu)||Feb 19 2018||3.2||Yes||No||No||Garbage||Bryan Quigley|
|Show||Arch Linux x86_64||Aug 08 2017||2.14-staging||Yes||Yes||Garbage||Marco|
|Show||Ubuntu 17.04 "Zesty" amd64 (+ variants like Kubuntu)||Mar 13 2017||2.3||Yes||Yes||Silver||Bryan Quigley|
CoH has a bug where the game can freeze if something else tries to take focus. A few things you can do to minimize the chances of your game freezing in the middle of play.