What does not
Needs some tinkering to get it run, see comments. Other than that, everything tested worked.
What was not tested
Needs the fake xlive.dll for bioshock2 to run, see http://timeslip.users.sourceforge.net/ Then you need no-dvd crack to pass securom. I used razor crack, google for it. You may need to apply the usual MousewarpOverride registry key. (If you run this on virtual desktop) you might need to prefix your launch command with env XMODIFIERS="". I have the steam version of the game. I have 3GHz Core2, 4GB RAM, Nvidia 260GTX, and the game runs smooth.
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Debian GNU/Linux Unstable "Sid"||Jan 05 2013||1.5.20||Yes||No||Garbage||Seegras|
|Show||Arch Linux x86_64||Dec 21 2012||1.5.20||Yes||No||Garbage||killown|
|Current||Fedora 7 x86_64||Mar 17 2011||1.3.14||Yes||Yes||Gold||kf|
|Show||Slackware64 -current||Dec 27 2010||1.3.10||Yes||No||Garbage||Zdenek Styblik|
|Show||Ubuntu 10.10 "Maverick" amd64 (+ variants like Kubuntu)||Oct 13 2010||1.3.4||Yes||No||Garbage||Scott Ritchie|