Mostly works as said by the other contributors.
I haven't been able to horizontally resize the rack but I don't remember if it was possible on windows (wasn't possible on Reason 2 back in the days).
The sequencer can be full-windowed tho
What does not
The application menu isn't clickable
What was not tested
Playing Reason directly via MIDI and wineasio
To use the App menu, alt and then down arrow worked for me (fix found on the Reason 4 DB page)
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Ubuntu 20.04 "Focal" (+ variants like Kubuntu)||Dec 12 2020||5.0.3||Yes||Yes||Yes||Gold||Marcel Bonnet|
|Show||Fedora 33 x86_64||Nov 25 2020||5.21-staging||Yes||Yes||Yes||Gold||enagok225|
|Current||Linux Mint Debian x86_64||Jun 02 2020||5.9||Yes||Yes||No||Silver||John|
|Show||Arch Linux x86_64||Aug 14 2016||1.9.14||Yes||Yes||Silver||an anonymous user|
|Show||Linux Mint 17 "Qiana" x86_64||Jul 21 2014||1.6.2||Yes||Yes||Silver||an anonymous user|