The vanilla game and a couple of the popular add ons work well.
In fact it works better on wine than on windows 7 for me (it suffers from very low framerates on win7)
What does not
The first start generates warnings about the version of directx
During the game the panel of controls and the planets sometimes disappear. It seems to happen particular during high atmospheric flight, at attitudes of a few degrees above the horizon and at low zoom. You can sometimes work around this by zooming in to a narrow field of view. It has less effect on ships with control panels, and more on those that depend on the default glass cockpit with mfd views.
What was not tested
The zip install (I installed the msi)
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Sabayon 9||Aug 17 2012||1.5.10||Yes||Yes||Gold||an anonymous user|
|Current||Ubuntu 12.04 "Precise" amd64 (+ variants like Kubuntu)||Apr 07 2013||1.4.1||Yes||Yes||Silver||James Kilfiger|
|Show||Ubuntu 10.10 "Maverick" i386 (+ variants like Kubuntu)||Feb 24 2011||1.3.14||Yes||Yes||Gold||James Whittamore|
|Show||Ubuntu 10.10 "Maverick" i386 (+ variants like Kubuntu)||Jan 30 2011||1.3.9||Yes||Yes||Silver||James Whittamore|
Tested with an ASUS P4P800E-deluxe mobo with P4 Prescott 3.2 GHz nudged up to 3.74 GHz, Nvidia GeForce 8400 GS pci, Western Digital Raptor 74 GB HDD, 4 GB of RAM. I just installed an Nvidia GeForce 7950 GT 8X AGP 512MB DDR3. Yesterday I stumbled across an Intel Pentium 4 EE 3.2GHz CPU SL7AA. I'm also going to add another Raptor for RAID0, and switch to LVM.