Everything, including mods (via Mod Organizer) with only a few workarounds needed. I've played for about 10 hours now with various mods and the workarounds listed below.
What does not
Exiting. As others have also said, exiting freezes/locks up the application and you must kill the now Defunct process TESV.exe from a terminal. I've not found a fix for this but it was suggested in a bug report this is due to the Dawnguard DLC being activated.
What was not tested
Needed a mod to fix seeing underwater (could only see green). Used "Green Water Fix V2 with Dawnguard" Had a weird shadow bug (same as this one https://www.youtube.com/watch?v=AlSNe_evsok) that I was able to resolve by setting "bDeferredShadows=0" in SkyrimPrefs.ini. See http://wiki.step-project.com/Guide:SkyrimPrefs_INI/Display#bDeferredShadows for what bDeferredShadows does.
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Current||Ubuntu 17.04 "Zesty" amd64 (+ variants like Kubuntu)||Aug 13 2017||2.14-staging||Yes||Yes||Gold||Thomas|
|Show||Ubuntu 16.04 "Xenial" amd64 (+ variants like Kubuntu)||Jun 10 2017||2.9-staging||Yes||Yes||Gold||Ruth Moreton|
|Show||Ubuntu 16.04 "Xenial" amd64 (+ variants like Kubuntu)||Apr 30 2017||2.7||Yes||Yes||Gold||Shadowsith|
|Show||Ubuntu 16.04 "Xenial" amd64 (+ variants like Kubuntu)||Feb 24 2017||2.0||Yes||Yes||Gold||Bogdan Marginean|
|Show||Debian GNU/Linux 8.x "Jessie" x86_64||Feb 19 2017||2.0||N/A||Yes||Silver||Centrino|
|Bug #||Description||Status||Resolution||Other apps affected|
|11674||Dual-core unsupported in WoW and SC2||STAGED||View|
|22053||Steam games crash on startup if in-game community is not disabled (gcc bug)||RESOLVED||NOTOURBUG||View|
|28282||Sound constantly crackling in lot of games||UNCONFIRMED||View|
|29067||Skyrim crashes during game intro||UNCONFIRMED||View|
|30123||Mouse pointer is confined in a box lesser than the full screen||REOPENED||View|
|30981||Skyrim: Keys "stick" occasionally||NEW||View|
|30984||Some keys do not work in different games (Trine, Skyrim, Dragon Age Origins, Dragon Age 2, Star Trek Online, Gothic 2)||NEW||View|
|32576||Skyrim doesn't display in-game content (Mesa built without floating-point texture support)||RESOLVED||NOTOURBUG||View|
|34041||Skyrim (Steam) hangup on quit||NEW||View|
|36059||Multiple Steam games fail to install DirectX runtime prerequisite, resulting in repeated install attempt on startup ('xinput1_3.dll' locked by client)||STAGED||View|
|37508||Some Bethesda games sometimes freeze during gameplay||UNCONFIRMED||View|
|37995||Mouse jittering when steam overlay is enabled||UNCONFIRMED||View|
|38211||Skyrim: freezes on opening screen||UNCONFIRMED||View|
|41262||It won't let me open Skyrim on my Steam||UNCONFIRMED||View|
Go to your home folder and "My Games"->"Skyrim"
Open the "SkyrimPrefs.ini" file.
Find the lines where you see "bFull Screen", "iSize H" and "iSize W"
and change their values to your desired resolution.
To fix crackling and choppy sound with Pulseaudio:
Possible fix 0:
run in some terminal:
while true; do pasuspender sleep 0.02; sleep 60; done
This finally prevents buffer underruns and the sound is perfect then.
Possible fix 1:
Make sure your realtime kit (rt-kit) is installed and functional so it can assign pulseaudio realtime priority. The kernel config CONFIG_RT_GROUP_SCHED needs to be off for this (see here).
Possible fix 2:
Setting SndQueueMax to 15 (default is 10), see here:
If you cannot see underwater (water is solid green):
Edit SkyrimPrefs.ini in your 'My Games\Skyrim' directory and in the [Imagespace] section set bDoDepthOfField=0 and iRadialBlurLevel=0
This is a game bug, not a Wine issue!
Stuck at main screen
Some mods change the fonts in Skyrim and sometimes that ends in wine not showing up the menu of Skyrim. Simple fix is to remove fontconfig.txt in Data/Interface.Crashes, texture bugs etc..
Remember, this is a Bethesda game, a few bugs happen for Windows users too, so blaming wine might not be justified. Please leave comments and bug reports, especially if things that used to work suddenly break.