Nealy everything until the transition from the 14th to the 15th (final) chapter, but the game can be finished. Read more below.
At install you must change SteamService.exe to run as Windows XP or the game won't install (afterwards you can run as Windows 7 normally).
What does not
Ambient Occlusion (tons of flicker) and Shadows in the "Very High" option. The game rarely have a very small lag and frameskips (mainly in cutscenes). 99% probability of an AMD's driver fault, not Wine's; because it works flawlessly in Windows 7 with the same hardware (except for the HD: the one with Ubuntu installed is much better). I love AMD, but unfortunately they don't take Linux seriously: months for an update, need to remove the driver at every kernel update (even the one installed by Jockey!!!)... A real headache.
In that, nVidia is 1.000 light years ahead.
What was not tested
Perfect until the transition from the 14th to the 15th (final) chapter. The game hanged and there was absolutely no workaround. Tried to install the PPA Wine 1.4.1 (didn't worked) and 1.5.28 (much worse: the game was unplayable). Had to run on a Windows 7 installed on an external HD only to complete the transition, then played back on Wine 1.4.1. Still, needed to be run on a 800x600 resolution with every graphic set at "Very Low". After you take the elevator (the problem seems to be with the aquarium in the first scene), you can set graphics to "High" (resolution can't be changed because there is no checkpoint. Graphics at "Very High" hangs the game). "This is not a game..." Phenom II X4 3.0 GHz - 4GB DDR3 RAM Video: ATI Radeon HD 6450 2GB MB DDR3 fglrx ver: 9.012-121219a-151962C-ATI (the AMD's site driver) Ubuntu 12.04 "Precise" 64 bits (kernel 3.2.0-40-generic #64-Ubuntu)
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Linux Mint 14 "Nadia"||Dec 14 2012||1.5.18||Yes||Yes||Silver||Carlos Rodriguez|
|Show||Ubuntu 12.04 "Precise" amd64 (+ variants like Kubuntu)||Jul 04 2012||1.5.7||Yes||Yes||Platinum||Wingnux|
|Current||Ubuntu 12.04 "Precise" amd64 (+ variants like Kubuntu)||Apr 27 2013||1.4.1||No, but has workaround||Yes||Gold||Krukutu|
|Show||Ubuntu 12.04 "Precise" amd64 (+ variants like Kubuntu)||Feb 10 2013||1.4||No, but has workaround||Yes||Gold||Krukutu|