I played it for an hour or so and had no problems like with other versions. It is playable even in higher resolutions, inventory works, sound too.
What does not
What was not tested
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Antergos x86_64||Apr 22 2017||2.6||Yes||Yes||Platinum||TehGuy|
|Show||Arch Linux x86_64||Jul 02 2014||1.7.21||Yes||Yes||Platinum||Joseph Williams|
|Show||Mac OS X 10.9 "Mavericks"||May 15 2014||1.7.18||Yes||Yes||Platinum||an anonymous user|
|Show||Arch Linux x86_64||Mar 08 2014||1.7.12||Yes||Yes||Platinum||Rob|
|Show||Ubuntu 13.04 "Raring" amd64 (+ variants like Kubuntu)||Jan 05 2014||1.7.9||Yes||Yes||Platinum||an anonymous user|
wine setup_system_shock2_18.104.22.168.exe /nogui
Has been suggested this 500meg+ update from Microsoft can help the more graphical installer.winetricks gdiplus
Make sure you are using a 32bit prefix if you're running a 64bit OS and have the required lib32's installed. This is generally good practice for wine at the time of writing.
For graphical specific glitches in game you can try modifying the entries in cam_ext.cfg. Read up on those if you don't know what they are and always keep a backup. cam.cfg contains more general game options.