Unity

What works

Installation,
scene editor and gui,
opening existing projects,
Linux export,
in editor play mode,
built-in monodevelop,
script and shader compilation,
importing with drag and drop from native file manager (Dolphin),
importing textures (including psd),
importing models (.fbx)

What does not

Asset store,
crating new projects,
"show in explorer" menu on assets does nothing,
"open" menu on assets (open wine internet explorer but the opened image doesn't work, probably another issue),
Direct3D11 rendering (activates but shaders fallback to SM3 as when the card doesn't suppot SM5) 

Workarounds

What was not tested

registering pro license and using pro features,
physics,
other exporters,
lots of stuff...

Hardware tested

Graphics:

• GPU:
• Driver:

Additional Comments

In order to make it run I had to do the following. Operation order is important, once done something inside the wine prefix - like installing .net - some tricks may not work afterwards. 1. install winetricks sudo apt-get install winetricks 2. set a win32 wine prefix export WINEARCH=win32 export WINEPREFIX=$HOME/.wine-u41 winecfg 3. Set up wine tricks: winetricks tahoma winetricks d3dx9 winetricks dotnet20 winetricks dotnet40 winetricks corefonts winetricks forcemono dotnet40 and corefonts may not be necessary, but Unity installs its bundled dotnet 4 which won't work so I did it anyway. 4. as suggested in comments made this directory, not sure if necessary mkdir -p $WINEPREFIX/drive_c/users/$USER/AppData/LocalLow 5. Recover a product ID from a valid windows install (XP in this case). Launch regedit on Windows machine and get value under HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProductId. Lounch regedit in wine and set the value (or make a .reg file like I did and import with wine regedit mykey.reg) 6. Normal setup wine ./UnitySetup-4.1.2.exe 7. Launch Unity, register and enjoy! NB: I used a separate prefix from .wine, this way you'll need to set env. variables from step 2 for normal execution as well. See more on bottles and prefixes.

1) Create 32bit prefix:
$ export WINEPREFIX=~/unity3dprefix
$ WINEARCH=win32 unitySetup.exe

2) Unity uses the Tahoma font, so for visible text you need to do:
$ winetricks tahoma

3) (Only for Wine <= 1.7.34, bug #26272 ) For working new project creation 
$ winetricks ie8

4) (Only for Wine <= 1.7.33, bug #36964 ) For working license you need to copy the ProductId value from 
HKLM\Software\Microsoft\Windows\CurrentVersion\ProductId
to 
HKLM\Software\Microsoft\Windows NT\CurrentVersion\ProductId
using: $ wine regedit
Or do:
$ wine reg add "HKLM\Software\Microsoft\Windows NT\CurrentVersion" /v ProductId /t REG_SZ /d 12345-oem-0000001-54321

5) (Only for Wine <= 1.7.23, bug #22896) For working editor after click "Play" - you need run:
$ mkdir -p $WINEPREFIX/drive_c/users/$USER/AppData/LocalLow

If you want edit code from linux version of monodevelop(or Xamarin Studio) - create link "C:" to drive_c of your prefix in project directory, that adds correct highlighting and autocomplete:
cd projectDirectory
ln -s ~/unity3dprefix/drive_c C:

If you want open Linux Monodevelop from unity use my script writted in python:
http://pastebin.com/W0whvbJ1 and save it as Monodevelop.exe
Select in unity as editor that script.

Wine bug #34039 makes it hard to use the Asset Store through the Asset Store window.

Assets from the Asset Store can be imported without opening the Asset Store, by using the Asset overview screen search function. Input the name of the asset and click on the button for searching within the Asset Store. This way, it is possible to import free and purchased assets.

You can download oifficial unity3d version for Linux.

Link