Everything except for Direct3D 10.
What does not
At first you will not be able to use substance designer. The 3D viewport will work however when trying to load/create a substance the program will crash. To fix this hit F9 on your keyboard and select SSE2 as the engine version. Close Substance Designer, open it back up, and try creating a new substance to see if it works. If that doesn't work and the program crashes upon substance creation then open your preferences by clicking on tools>preferences and selecting the 3D View menu. Uncheck the Post Process enabled box and then retry.
What was not tested
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Current||Ubuntu 15.04 "Vivid" amd64 (+ variants like Kubuntu)||Jun 21 2015||1.7.45||Yes||Yes||Gold||Carl Gessau|