I think everything in wine64 prefix, and suprisingly enough the game has decent performance with my hardware cpu:fx 8300 gpu: r7 240
What does not
The game does not launch from the launcher (just launch it from fallout4.exe)
Exiting from in-game to desktop crashes wine (not serious)
Mouse bug and no audio, but there are workarounds.
I installed xact to make audio work. Enabled csmt from winecfg,installed d3d_43 compiler&dxfull setup and disabled godrays from the launcher options to make the game launch.
Now for the mousebug:
Edit [Fallout4_Default.ini] (located in game folder) and [Fallout4.ini,Fallout4Custom.ini,Fallout4Prefs.ini] (located in --->my documents--->my games--->fallout4) and add bBackgroundMouse=1 so that the "controls section" in all of the .ini files looks like this:
What was not tested
If you are using xfce4 disable the desktop compositor before launching the game, otherwise the game will run in slow motion, at least that's the case with my gpu and my setup.
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Current||Arch Linux x86_64||Dec 11 2017||2.21-staging||Yes||Yes||Yes||Silver||siyia|
|Show||Arch Linux x86_64||Nov 23 2017||2.21-staging||Yes||Yes||Yes||Silver||Nickolay|
|Show||Arch Linux x86_64||Oct 24 2017||2.19-staging||Yes||Yes||Yes||Silver||Clock|
|Show||Fedora 25 x86_64||Oct 11 2017||2.18||Yes||Yes||Yes||Garbage||Alexander Richards|
|Show||Ubuntu 16.04 "Xenial" amd64 (+ variants like Kubuntu)||Oct 02 2017||2.18-staging||Yes||Yes||Yes||Silver||Mork|
|Bug #||Description||Status||Resolution||Other apps affected|
|38648||Multiple games and applications need support for Mesa OpenGL >= 3.2 core profiles, Shader Model 4, GLSL 1.50 (Microsoft Office 2013 installer, .NET/XNA games)||NEW||View|
|40976||Multiple games needs d3d11_device_CreateTexture1D implementation||STAGED||View|
|41271||Fallout 4 - Audio issues (no sounds, hangs when playing intro video)||UNCONFIRMED||View|
|42631||Mouse input cause camera drift or jump in Fallout 4 and Unity-engine games ( fixed in Unity-engine games, have walkaround in Fallout4 )||UNCONFIRMED||View|
To run the game at DirectX 9 level, you can use the dxcpl.exe tool to translate DX11 to DX9.