The Sims 4.
The game itself runs just like in Windows
What does not
Origin In-Game (not part of the game)
Requires to install Visual C++ .dll/s using latest version of winetricks
winetricks vcrun2010 vcrun2013 vcrun2017
and Origin (no need for workarounds to install it).
It's also neccesary to disable Origin In-Game in settings, otherwise the game will crash.
If the "Play" button is greyed-out for you after Origin completed downloading and installation, terminate its process, launch again and run repair on the game in the menu, you should be able to launch it now.
What was not tested
Origin In-Game functions
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Show||Arch Linux x86_64||Apr 18 2021||6.6||Yes||Yes||No||Silver||Nobody|
|Show||Manjaro Linux||Nov 16 2020||5.20-staging||Yes||Yes||No||Platinum||Steven|
|Show||KDE Neon 5.18||Sep 12 2020||5.17||No, but has workaround||Yes||Yes||Silver||Alex Lowe|
|Show||Ubuntu 20.04 "Focal" (+ variants like Kubuntu)||Aug 20 2020||5.0.2||Yes||Yes||Yes||Silver||Tyson Roberts|
|Show||Fedora 32 x86_64||Jul 21 2020||5.12-staging||Yes||No||No||Garbage||Jonas Thiem|
|Bug #||Description||Status||Resolution||Other apps affected|
|38437||Sims 4 crashes after 5-20 minutes||NEEDINFO||View|
|39689||The Sims 4 crashes on start (exception in MSVCRT)||UNCONFIRMED||View|
|42467||The Sims 4 Origin crashes||CLOSED||DUPLICATE||View|
|43992||Sims 4 won't start, wine skips .dlls||CLOSED||DUPLICATE||View|
|44041||The Sims 4 instant-aborts claiming Origin doesn't run||UNCONFIRMED||View|
|44999||Python 3.6.5 crashes due to unimplemented function api-ms-win-core-path-l1-1-0.dll.PathCchCanonicalizeEx.||CLOSED||FIXED||View|
|49600||Newest Sims 4 crashes at every launch with slightly different error, critical section/threading failure?||CLOSED||WORKSFORME||View|