Single player works beautifully at 2560x1440 with antialiasing on a GeForce GTX 1060 (struggled at 4K).
Sometimes sound gets slightly out of sync then corrects itself, mostly in cut scenes. Once someone I was talking to was invisible sometimes, that could be a bug in the game though.
Imported a character from ME2 on Steam by copying Save from
steamapps/compatdata/24980/pfx/drive_c/users/steamuser/My\ Documents/BioWare/Mass\ Effect\ 2/
to My Documents in the Wineprefix (symlinked to Documents in my home dir).
What does not
Origin install failed with 64bit Wineprefix.
Origin In Game caused the game to crash on start.
DLC downloads in Origin were shonky.
To install Origin I used the legacy installer and created a 32bit Wineprefix as described in https://wiki.winehq.org/FAQ#Wineprefixes
I disabled Origin In Game in the ME3 properties in Origin, otherwise it crashed on start.
The DLC downloads kept hanging in Origin, I used a combination of pausing and resuming, and restarting Origin to get them going again.
What was not tested
|Operating system||Test date||Wine version||Installs?||Runs?||Used|
|Current||Ubuntu 18.04 "Bionic" amd64 (+variants like Kubuntu)||Oct 21 2019||4.18-staging||Yes||Yes||Yes||Gold||Barney Livingston|
|Show||Ubuntu 18.04 "Bionic" amd64 (+variants like Kubuntu)||Feb 23 2019||4.2||No||Not installable||No||Garbage||Wang Xuancong|
|Show||Arch Linux x86_64||Feb 06 2019||4.0-rc4-staging||Yes||Yes||No||Platinum||Eimantas|
|Show||Manjaro Linux 18.0.0||Oct 18 2018||3.18||Yes||Yes||No||Garbage||Roque|
|Show||Linux Mint 18.3 "Sylvia" x86_64||Jun 04 2018||3.9-staging||Yes||Yes||No||Garbage||James Edmonds|