Reason

What works

• installing
• licensing*
• audio output
• MIDI input/output (tested MIDI piano and Korg NanoKontrol2, there's a rather high latency though)
• loading/saving**
• audio exporting**
• MIDI export/import**
• editing in sequencer
• editing and routing of native rack devices in the rack
• VST plugins***

* Reason licensing works perfectly, but rack extensions doesn't work due to disconnected of Authorizer.

** In some cases only Drag-and-Drop is working.

*** Only a few of them (like 3) can be active at a time.

What does not

• Menu doesn't work as expected (you have to press Alt once and then press Up or Down Arrow key to invoke the menu and list through them using left and right Arrow keys).
• Any loading using Reason's inbuilt file browser doesn't work
• Clicking any category in Browser except "Instruments", "Effects", "Utilities", "Players" and "Showcase" triggers "Unknown exception."
• Authorizer seems to have no connection to web browser to obtain the licenses from Reason Studios Account.
• VST Plugins seems to have a limitation of only three of them active at the same time
• Menu doesn't work as expected (you have to press Alt once and then press Up or Down Arrow key to invoke the menu and list through them using left and right Arrow keys).
• Any loading (songs, audio files, MIDI files, patches...) using Reason's inbuilt file browser doesn't work. 
• Clicking any category in Browser except "Instruments", "Effects", "Utilities", "Players" and "Showcase" triggers "Unknown exception."
• Authorizer seems to have no connection to web browser to obtain the licenses from Reason Studios Account. 
• Recording (tested with Focusrite Scarlett).
• VST Plugins seems to have a limitation of only three of them active at the same time. 
• Some parts of UI are not displayed properly.

Workarounds

What was not tested

None. I tested it rather well and for longer time (also with Wine 4.16 before).

Hardware tested

Graphics:

• GPU: Nvidia
• Driver: proprietary

Additional Comments