Note: if your mouse sensitivity is high enough the cursor might jump out of the game window if you move your mouse fast, you could prevent this by using slower speed in X and higher sensitivity in game but you'll lose some accuracy
Intro movies cannot be skipped. Only way to do it is to remove the intro movies permanently or to replace them with empty files (might produce better results). The correspondig files are Videos/Logos.bik and Videos/int/RS_Intro.bik. If you happen to have crashing problems with the intro videos, this also gets you into the menu.
Multiplayer works flawlessly.
Intro movies are not skippable or might crash the game (workaround exists)
Mission planning menu may be garbage. You might be able to start the mission by blindly clicking at the lower right corner with the default plan. Some users report they do not have this issue or it works most of the time.
Some artifacts of the player models might appear in your hud, particulary at bottom left, not affecting the gameplay
Some snow textures are drawn black or can be seen trough (fixed in >= 1.1.3)
Mouse can't be used in the menu (workaround in >= 1.1.3)
When completing a mission Raven Shield crashes (fixed in >= 1.1.3)
Mission planning menu is garbage after finishing a mission (partially fixed in >= 1.1.3)
Everything above was tested with Wine 1.1.3.
Warning about Punkbuster
Punkbuster might or might not work. You will be kicked out of Punkbuster enabled servers without patching and can be marked as a cheater, so be careful!